Accelerate your biostructural research
Until now, SAXS measurements on biological samples were limited to synchrotron facilities or low throughput laboratory setups requiring large sample volumes. The BioXolver with its unique features overcomes these limitations. It offers:
- High quality data
- Full automation of multi-sample measurements and data analysis
- The capability to work reliably with very small volumes of sample
- Best of all, this capability is available right in your lab, allowing you to shorten your development cycle and accelerate your bio-structural research
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Discovering macromolecular shape and interactions Using Small angle X-ray scattering (SAXS), the BioXolver collects The BioXolver can obtain key structural parameters, such as:
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In-lab SEC-SAXS, protein-protein interactions... Discover our application notes : High-throughput 3D protein envelope Thorough investigation of oligomers during protein fibrillation Protein-protein interactions – from in vivo functionality to pharmaceutics and food science In-lab SEC-SAXS for structural investigation of complex samples |
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High quality SAXS data in the lab Measurements previously only possible at synchrotron facilities can now be done in the lab. With the BioXolver you get:
Due to weak scattering from biological samples, high quality SAXS measurements require an instrument optimized for maximum X-ray intensity and lowest possible background noise. The BioXolver offers a unique combination of both capabilities. |
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High throughput measurements and results Full automation from sample to final results on up to 192 samples. With the BioXolver standard well plates can be loaded & measured automatically using in-line pipetting robot & automated software suite for high user benefits.
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Low sample volume consumption Down to 5μL. The lowest sample consumption on the market. High precision positioning of small sample volumes is ensured by the conjunction of an in-line pipetting robot and the BioCUBE, an advanced capillary flow cell, coupled to machine vision for sample monitoring. Such low total consumption per sample condition or concentration is highly beneficial for biostructural research.
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In-line SEC and UV-Vis combined with SAXS – also in the lab! Obtain the structure of small and large protein species through in-line gel filtration Sample size separation using size-exclusion chromatography in combination with the BioXolver can not only be used to ensure clean monodisperse samples, but also facilitates research on structurally heterogeneous & aggregation-prone multi-domain proteins as well as heterogeneous protein complexes in dynamic equilibria. |
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